Structure of PDB 2zuf Chain A Binding Site BS01

Receptor Information
>2zuf Chain A (length=628) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LMEIRESVKERIEEIIKEIAPQWEGEIELKETPDPKLGDFGTPIAFKLAK
LLKRPPIEIAEKIVEKLKLNLPEGIKDVKAVNGYINVFIDYPHFARILIN
DILAKGDRFGSSEIGKGKKVIVEHTSVNPTKPLHMGHARNAILGDVMARI
LRFLGYEVEVQNYIDDLGIQFAQVYWGYLRLKEEFERIMNELRERGLKDN
PIDHALGLLYVEVNRRLEDNPELENEIRDIMKKLESGELYGRKLAEEVVR
AQMVTTYKLGVKYDLLVWESDIVRRKLFEIALELLSKNENFYIPSDGKYR
GAFVMDLRKLFPDMKNPILVLRRSDGTATYTGKDIAYHLWKFGKIDVDLL
YKEWDSTTWTTAPDGKSMPNKFGNANIVINVIGAEQKHPQLAIKYALQLL
GFEDAAANLYHLAYEHVERPEGKFSGRKGTWVGFTVDEVIQEAVKRAREL
IEEKNPALSDEEKAEVAEKVGIGAIRYNLIKYSPDKKIIFRWEDVLNFEG
ESAPYIQYAHARCSSILRKAEEEGIKVDPETLFKNADFTKLSERERELVI
MLSKFPRIVEQAGKDVKPHLIAWFANELASLFNKFYMDHPVLKAEEGVRE
ARLLLVMAVEQVLKNALYLMGIEAPERM
Ligand information
>2zuf Chain B (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggaccgguagccuagccaggacagggcggcggccuccuaagccgcagguc
cgggguucaaauccccgccgguccgc
<<<<<<<..<<<<..........>>>>.<<<<<.......>>>>>.....
<<<<<.......>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2zuf Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP)
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K31 P34 L38 P44 F47 K48 K51 Y85 N87 Y300 V321 R324 S325 E386 K388 H389 K424 L451 K455 Y483 S484 D486 K487 G501 E502 Y506 Y509 R513 S516 I517 K585 Y587 M588 H590 V592 L593 R628 M629
Binding residue
(residue number reindexed from 1)		K30 P33 L37 P43 F46 K47 K50 Y84 N86 Y299 V320 R323 S324 E385 K387 H388 K423 L450 K454 Y482 S483 D485 K486 G500 E501 Y505 Y508 R512 S515 I516 K584 Y586 M587 H589 V591 L592 R627 M628
Enzymatic activity
Catalytic site (original residue number in PDB) K132 H135 H138
Catalytic site (residue number reindexed from 1) K131 H134 H137
Enzyme Commision number 6.1.1.19: arginine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004814 arginine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2zuf, PDBe:2zuf, PDBj:2zuf
PDBsum2zuf
PubMed19656186
UniProtO59147|SYR_PYRHO Arginine--tRNA ligase (Gene Name=argS)

[Back to BioLiP]