Structure of PDB 2zti Chain A Binding Site BS01

Receptor Information

>2zti Chain A (length=184) Species: 53953 (Pyrococcus horikoshii)

MKIFFITSNPGKVREVANFLGTFGIEIVQLKHEYPEIQAEKLEDVVDFGI
SWLKGKVPEPFMIEDSGLFIESLKGFPGVYSSYVYRTIGLEGILKLMEGA
EDRRAYFKSVIGFYIDGKAYKFSGVTWGRISNEKRGTHGFGYDPIFIPEG
SEKTFAEMTIEEKNALSHRGKALKAFFEWLKVNL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2zti Chain A Residue 187

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2zti Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3: functional significance of interprotomer conformational changes
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): E36 D65
• Binding residue (residue number reindexed from 1): E36 D65
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.1.66: XTP/dITP diphosphatase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016787 hydrolase activity
• GO:0017111 ribonucleoside triphosphate phosphatase activity
• GO:0035870 dITP diphosphatase activity
• GO:0036220 ITP diphosphatase activity
• GO:0036222 XTP diphosphatase activity
• GO:0046872 metal ion binding
• GO:0047429 nucleoside triphosphate diphosphatase activity

Biological Process

• GO:0009117 nucleotide metabolic process
• GO:0009143 nucleoside triphosphate catabolic process
• GO:0009146 purine nucleoside triphosphate catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2zti, PDBe:2zti, PDBj:2zti
• PDBsum: 2zti
• PubMed: 18062990
• UniProt: O59580|IXTPA_PYRHO dITP/XTP pyrophosphatase (Gene Name=PH1917)