Structure of PDB 2zpq Chain A Binding Site BS01

Receptor Information

>2zpq Chain A (length=220) Species: 8018 (Oncorhynchus keta)

IVGGYECKAYSQPHQVSLNSGYHFCGGSLVNENWVVSAAHCYKSRVEVRL
GEHNIKVTEGSEQFISSSRVIRHPNYSSYNIDNDIMLIKLSKPATLNTYV
QPVALPSSCAPAGTMCTVSGWGNTMSSTADKNKLQCLNIPILSYSDCNNS
YPGMITNAMFCAGYLEGGKDSCQGDSGGPVVCNGELQGVVSWGYGCAEPG
NPGVYAKVCIFNDWLTSTMA

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2zpq Chain A Residue 3001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2zpq A structural comparison of three isoforms of anionic trypsin from chum salmon (Oncorhynchus keta).
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): E52 N54 V57 E59 E62
• Binding residue (residue number reindexed from 1): E52 N54 V57 E59 E62
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H40 D84 Q173 G174 D175 S176 G177
• Catalytic site (residue number reindexed from 1): H40 D84 Q173 G174 D175 S176 G177

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:2zpq, PDBe:2zpq, PDBj:2zpq
• PDBsum: 2zpq
• PubMed: 19564692
• UniProt: Q8AV11