Structure of PDB 2znr Chain A Binding Site BS01

Receptor Information
>2znr Chain A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPGHMEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTI
THVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSS
VDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFH
PHTKEPRLFSICKHVLVKDIKIIVLDLR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2znr Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2znr Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
Resolution1.2 Å
Binding residue
(original residue number in PDB)		H362 C402 H408 H410
Binding residue
(residue number reindexed from 1)		H104 C144 H150 H152
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0061578 K63-linked deubiquitinase activity
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination
GO:0070536 protein K63-linked deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:2znr, PDBe:2znr, PDBj:2znr
PDBsum2znr
PubMed18758443
UniProtQ96FJ0|STALP_HUMAN AMSH-like protease (Gene Name=STAMBPL1)

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