Structure of PDB 2zhh Chain A Binding Site BS01

Receptor Information
>2zhh Chain A (length=120) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAI
IKIAQRIGIPLATIGEAFGVTLSAKEWKQLSSQWREELDRRIHTLVALRD
ELDGCIGCGCLSRSDCPLRN
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain2zhh Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zhh Crystal structure of the [2Fe-2S] oxidative-stress sensor SoxR bound to DNA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C119 C122 G123 C124 L125 C130
Binding residue
(residue number reindexed from 1)		C105 C108 G109 C110 L111 C116
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006979 response to oxidative stress
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2zhh, PDBe:2zhh, PDBj:2zhh
PDBsum2zhh
PubMed18334645
UniProtP0ACS2|SOXR_ECOLI Redox-sensitive transcriptional activator SoxR (Gene Name=soxR)

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