Structure of PDB 2zet Chain A Binding Site BS01

Receptor Information
>2zet Chain A (length=181) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYD
TQGASGKAFKVHLQLWDTAGLERFRSLTTAFFRDAMGFLLMFDLTSQQSF
LNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELAEKYGI
PYFETSAATGQNVEKSVETLLDLIMKRMEKC
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2zet Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zet Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T23 T41
Binding residue
(residue number reindexed from 1)		T19 T37
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
GO:0031489 myosin V binding
Biological Process
GO:0017157 regulation of exocytosis
GO:0045921 positive regulation of exocytosis
GO:0048488 synaptic vesicle endocytosis
GO:0071985 multivesicular body sorting pathway
GO:0099641 anterograde axonal protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030672 synaptic vesicle membrane
GO:0032585 multivesicular body membrane
GO:0042470 melanosome
GO:0042589 zymogen granule membrane
GO:0043231 intracellular membrane-bounded organelle
GO:1904115 axon cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zet, PDBe:2zet, PDBj:2zet
PDBsum2zet
PubMed18940604
UniProtQ99P58|RB27B_MOUSE Ras-related protein Rab-27B (Gene Name=Rab27b)

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