Structure of PDB 2zcv Chain A Binding Site BS01

Receptor Information

>2zcv Chain A (length=283) Species: 562 (Escherichia coli)

MIAITGATGQLGHYVIESLMKTVPASQIVAIVRNPAKAQALAAQGITVRQ
ADYGDEAALTSALQGVEKLLLISSSEVGQRAPQHRNVINAAKAAGVKFIA
YTSLLHADTSPLGLADEHIETEKMLADSGIVYTLLRNGWYSENYLASAPA
ALEHGVFIGAAGDGKIASATRADYAAAAARVISEAGHEGKVYELAGDSAW
TLTQLAAELTKQSGKQVTYQNLSEADFAAALKSVGLPDGLADMLADSDVG
ASKGGLFDDSKTLSKLIGHPTTTLAESVSHLFN

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2zcv Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2zcv Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): E276 H280
• Binding residue (residue number reindexed from 1): E276 H280
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.6.5.2: NAD(P)H dehydrogenase (quinone).

Gene Ontology

Molecular Function

• GO:0003955 NAD(P)H dehydrogenase (quinone) activity
• GO:0008753 NADPH dehydrogenase (quinone) activity
• GO:0016491 oxidoreductase activity
• GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
• GO:0050136 NADH:ubiquinone reductase (non-electrogenic) activity

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:2zcv, PDBe:2zcv, PDBj:2zcv
• PDBsum: 2zcv
• PubMed: 18455185
• UniProt: P39315|QOR2_ECOLI Quinone oxidoreductase 2 (Gene Name=qorB)