Structure of PDB 2z7x Chain A Binding Site BS01

Receptor Information
>2z7x Chain A (length=549) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCV
NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSL
TFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFL
EELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC
LELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQI
SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFY
DLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEY
LKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH
SMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNL
PQLKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQ
KIWLHTNPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGKPVRSIICP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2z7x Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Resolution2.1 Å
Binding residue
(original residue number in PDB)		N294 Y326 D327
Binding residue
(residue number reindexed from 1)		N268 Y300 D301
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z7x, PDBe:2z7x, PDBj:2z7x
PDBsum2z7x
PubMed17889651
UniProtO60603|TLR2_HUMAN Toll-like receptor 2 (Gene Name=TLR2)

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