Structure of PDB 2z5k Chain A Binding Site BS01

Receptor Information
>2z5k Chain A (length=840) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVL
TKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSP
LIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQK
ICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS
RTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHM
HNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVL
VNGMKYSDIDIILLKDDDTISDWNLRKCSAAALDVLANVYRDELLPHILP
LLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDK
KALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAA
CSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLAD
SVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSG
FLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSG
LAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQ
HVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMV
LHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTS
LRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLR
DMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Ligand information
Receptor-Ligand Complex Structure
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PDB2z5k Structural basis for substrate recognition and dissociation by human transportin 1
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K377 A380 D384 L419 W460 R495 S502 E509 D543
Binding residue
(residue number reindexed from 1)		K327 A330 D334 L369 W410 R445 S452 E459 D493
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005929 cilium
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z5k, PDBe:2z5k, PDBj:2z5k
PDBsum2z5k
PubMed17936704
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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