Structure of PDB 2z4g Chain A Binding Site BS01

Receptor Information
>2z4g Chain A (length=263) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVDSHVHTPLCGHAEGHPEAYLEEARAKGLKGVVFTDHSPMPPWYDPESR
MRLEALPFYLLALERVRERAQDLYVGIGLEADFHPGTEGFLAQLLRRYPF
DYVIGSVHYLGAWPLDHPDHQEEYAWRDLKEVFRAYFQEVEKAARSGLFH
AIGHLDLPKKFGHRLPEEALLELAEPALRAVAEAGLFLDVNTAGLRRPAK
EVYPAPALLRRARELGIGLVLGSDAHRPEEVGFAFPEVQALLAGLGFREA
YYFVEGSPVAYPL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2z4g Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2z4g Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase from Thermus thermophilus HB8.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H13 H38 H226
Binding residue
(residue number reindexed from 1)		H13 H38 H226
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.15: histidinol-phosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004401 histidinol-phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z4g, PDBe:2z4g, PDBj:2z4g
PDBsum2z4g
PubMed17929834
UniProtQ5SLG2

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