Structure of PDB 2yv9 Chain A Binding Site BS01

Receptor Information
>2yv9 Chain A (length=285) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMAEAYQIQSNGDPQSKPLLELYVKASGIDARRIGADLFCQEFWMELYAL
YEIGVARVEVKTVNVNSEAFKKNFLGAQPPIMIEEEKELTYTDNREIEGR
IFHLAKEFNVPLFEKDPSAEKRIENLYRNFKLFLRAKVEFDKGKKEPSRV
EDLPAQIKVHYNRVCEQLSNIDQLLSERKSRYLLGNSMTEYDCELMPRLH
HIRIIGLSLLGFDIPHNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKE
QMNLFTNQRETLQSPTKTHTIPEKVLSDIRVKGLA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2yv9 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2yv9 Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC
Resolution1.6 Å
Binding residue
(original residue number in PDB)		Q77 P79 T91 N93
Binding residue
(residue number reindexed from 1)		Q78 P80 T92 N94
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
Biological Process
GO:0002064 epithelial cell development
GO:0006821 chloride transport
GO:0034220 monoatomic ion transmembrane transport
GO:0035150 regulation of tube size
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0034707 chloride channel complex
GO:0043296 apical junction complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yv9, PDBe:2yv9, PDBj:2yv9
PDBsum2yv9
PubMed17985355
UniProtQ8WQA4|EXC4_CAEEL Chloride intracellular channel exc-4 (Gene Name=exc-4)

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