Structure of PDB 2yep Chain A Binding Site BS01

Receptor Information
>2yep Chain A (length=173) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPRGFVVHTAPVGLADDGRDDFTVLASTAPATVSAVFTRSRFAGPSVVLC
REAVADGQARGVVVLARNANVATGLEGEENAREVREAVARALGLPEGEML
IASTGVIGRQYPMESIREHLKTLEWPAGEGGFDRAARAIMTTDTRPKEVR
VSVGGATLVGIAKGVGMLEPDMA
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain2yep Chain B Residue 1601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2yep Structural and Biochemical Analyses Reveal How Ornithine Acetyl Transferase Binds Acidic and Basic Amino Acid Substrates.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		T148 T149 D150 G171 V172 G173
Binding residue
(residue number reindexed from 1)		T141 T142 D143 G164 V165 G166
Annotation score5
Enzymatic activity
Enzyme Commision number 2.3.1.35: glutamate N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0004358 glutamate N-acetyltransferase activity
Biological Process
GO:0006526 L-arginine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2yep, PDBe:2yep, PDBj:2yep
PDBsum2yep
PubMed21796301
UniProtP0DJQ5|GNAT2_STRCL Glutamate N-acetyltransferase 2 (Gene Name=oat2)

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