Structure of PDB 2y35 Chain A Binding Site BS01

Receptor Information

>2y35 Chain A (length=1026) Species: 7227 (Drosophila melanogaster)

MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPFHLE
EEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAR
EAEQQEAKAAQRRFDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRC
TVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDAALIILGL
CTHELHFVVLREEVKFGRNVKRTSVEETRFFLLHLGLLREYLELEFDALR
TDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGI
YPTLGGNINENGKLNLRRLQIFISALTEVELDHFKEHADDDENAVLLKEF
QNYKRNFYRNKFKRDPNDELIEELCHHYVNALQWVLDYYYRGVQSWDWYY
PFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAKLLPVAYH
DLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPC
EAQLSLEERERNRHGPMYVYKYSTVAQGPMPAYPPLRALPVLYCTEVAKW
SHEIAVNLPYSVCIELPNAARTVFFPGFPTMQHLPFDFELRNDRVKVFEQ
VSRNQNIVLKPRKRQLEDTLTAVASQYLGKVIHVGWPHLVKAIVVRVATR
DQRVDSEGITLNDSRRFDSECKALQEHFINRMGIQFANYDVLVYVRTFAG
NSTEFRDKGALMVRDSWSSSVTGYPAQGVVADLTVWERKNFLNVEHYFPV
GSTIFLITDPYYGSEGTVQDPRRIQVSIMVRPEPKVNAARQLQEERDRDY
LSTFQVCNLLRISGRTLGRLSGTVWVVHNIGLQLKYPRQNEERAGYCFRT
NNQWYYSSLAVDLMRNYCQRYPDVIDFFGDSNGHRRVEELANWVRQQPHM
KVERISCGSKTVCRETIELLIAAVDDLRKHVKLQVKPHLLIKPNVTLPDV
YRSKRPVRLFDRVVIVRTIYMVPVGTKGTVIGIHPVTDPNPVRLECVHAV
DTFCKVLFDSPVRVYKVPEIALVIIK

Ligand information

>2y35 Chain B (length=4)

tttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2y35 Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): M1 K5 N37 H41 K93 R100 R101 W540
• Binding residue (residue number reindexed from 1): M1 K5 N37 H41 K87 R94 R95 W479

Enzymatic activity

• Enzyme Commision number: 3.1.13.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity
• GO:0008409 5'-3' exonuclease activity

Biological Process

• GO:0000956 nuclear-transcribed mRNA catabolic process

External links

• PDB: RCSB:2y35, PDBe:2y35, PDBj:2y35
• PDBsum: 2y35
• PubMed: 21362555
• UniProt: E1JJR3