Structure of PDB 2xzo Chain A Binding Site BS01

Receptor Information
>2xzo Chain A (length=613) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKR
IAYFTLPRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRS
SVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLG
HEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTG
KTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAK
SREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKELSSADEKRYRALKRT
AERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV
LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ
YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVT
QGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRS
YLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIG
FLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEG
PLNNLRESLMQFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2xzo Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Resolution2.395 Å
Binding residue
(original residue number in PDB)		Y316 K321 T418 S419 P522 S523 N524 A546 K547 S548 T616 V618 M671 T762 S763 Y796 E797 S825 D827 G851 F852
Binding residue
(residue number reindexed from 1)		Y25 K30 T121 S122 P225 S226 N227 A249 K250 S251 T315 V317 M370 T461 S462 Y495 E496 S524 D526 G550 F551
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2xzo, PDBe:2xzo, PDBj:2xzo
PDBsum2xzo
PubMed21419344
UniProtQ92900|RENT1_HUMAN Regulator of nonsense transcripts 1 (Gene Name=UPF1)

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