Structure of PDB 2xz4 Chain A Binding Site BS01

Receptor Information
>2xz4 Chain A (length=165) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HILDRSEWLGEPPSGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTI
QAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWHIQGQHVNGYGAISVSIAF
IGTFVNMEPPARQIEAAKRLMDEGVRLHRLQPDYHIYAHRQLSPTESPGQ
KLFELMQNWPRFTQD
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain2xz4 Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2xz4 The Drosophila Peptidoglycan-Recognition Protein Lf Interacts with Peptidoglycan-Recognition Protein Lc to Downregulate the Imd Pathway.
Resolution1.72 Å
Binding residue
(original residue number in PDB)		I59 E64
Binding residue
(residue number reindexed from 1)		I2 E7
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) Y122
Catalytic site (residue number reindexed from 1) Y65
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0042834 peptidoglycan binding
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0045087 innate immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:2xz4, PDBe:2xz4, PDBj:2xz4
PDBsum2xz4
PubMed21372849
UniProtQ8SXQ7|PGPLF_DROME Peptidoglycan-recognition protein LF (Gene Name=PGRP-LF)

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