Structure of PDB 2xxm Chain A Binding Site BS01

Receptor Information
>2xxm Chain A (length=73) Species: 12721 (Human immunodeficiency virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNAN
PDCKTILKALGPGATLEEMMTAC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2xxm Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors
Resolution1.65 Å
Binding residue
(original residue number in PDB)		V165 D166 Y169 L172 R173 Q179 K182 N183 T186 E187 L211 M214 M215
Binding residue
(residue number reindexed from 1)		V20 D21 Y24 L27 R28 Q34 K37 N38 T41 E42 L66 M69 M70
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
External links
PDB RCSB:2xxm, PDBe:2xxm, PDBj:2xxm
PDBsum2xxm
PubMed
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

[Back to BioLiP]