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Receptor Information

>2xs8 Chain A (length=697) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRR
AAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDK
GSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAK
HYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFL
KATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCI
MQANAEYHQSILAKQQYYFGEEIARLQHAAELIKTVASRYDEYVNVKDFS
DKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKF
TDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNL
PAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREIL
DESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDK
AVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNV
LKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSV
TELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREE
VLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFAR

>2xs8 Chain B (length=9) Species: 11723 (Simian immunodeficiency virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AYDPARKLL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2xs8 Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1.
Resolution	2.498 Å
Binding residue (original residue number in PDB)	V498 A505 D506 N669 E672 G673 F676 E679
Binding residue (residue number reindexed from 1)	V497 A504 D505 N668 E671 G672 F675 E678

Enzyme Commision number

	Biological Process
GO:0071985	multivesicular body sorting pathway

PDB	RCSB:2xs8, PDBe:2xs8, PDBj:2xs8
PDBsum	2xs8
PubMed	20962096
UniProt	Q8WUM4\|PDC6I_HUMAN Programmed cell death 6-interacting protein (Gene Name=PDCD6IP)

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Structure of PDB 2xs8 Chain A Binding Site BS01