Structure of PDB 2xrw Chain A Binding Site BS01

Receptor Information
>2xrw Chain A (length=349) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILER
NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE
FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHR
DLKPSNIVVKSDCTLKILDFGLRYYRAPEVILGMGYKENVDIWSVGCIMG
EMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKY
AGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL
QHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2xrw Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
Resolution1.33 Å
Binding residue
(original residue number in PDB)		Q117 M121 E126 R127 Y130 K160 S161 D162 C163
Binding residue
(residue number reindexed from 1)		Q117 M121 E126 R127 Y130 K160 S161 D162 C163
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D151 K153 N156 D169
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xrw, PDBe:2xrw, PDBj:2xrw
PDBsum2xrw
PubMed23047924
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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