Structure of PDB 2xhb Chain A Binding Site BS01

Receptor Information
>2xhb Chain A (length=741) Species: 71997 (Thermococcus gorgonarius) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MILDTDYITEDGKPVIRIFKKENGEFKIDYDRNFEPYIYALLKDDSAIED
VKKITAERHGTTVRVVRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKI
KEHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMLAFDIETLEFAEG
PILMISYADEEGARVITWKNIDLPYVDVVSTEKEMIKRFLKVVKEKDPDV
LITYNGDNFAFAYLKKRSEKLGVKFILGREGSEPKIQRMGDRFAVEVKGR
IHFDLYPVIRRTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWETGEGL
ERVARYSMEDAKVTYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEW
FLLRKAYERNELAPNKPDAGGYVKEPERGLWENIVYLDFRSLYPSIIITH
NVSPDTLNREGCEEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKVKKK
MKATIDPIEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAW
GRQYIETTIREIEEKFGFKVLYADTDGFFATIPGADAETVKKKAKEFLDY
INAKLPGLLELEYEGFYKRGFFVTKKKYAVIDEEDKITTRGLEIVRRDWS
EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIYEQI
TRDLKDYKATGPHVAVAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAIP
FDEFDPAKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2xhb Probing the Interaction of Archaeal DNA Polymerases with Deaminated Bases Using X-Ray Crystallography and Non-Hydrogen Bonding Isosteric Base Analogues.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		Y7 P36 Y37 P90 V93 R97 Y112 D113 I114 P115 F116 K118 N210 N213 F214 M244 D246 R247 Y261 R265 T272 Y273 L275 D343 S348 K371 Y499 R612 R613 D614 E664 Q665 T667 R668 Y673 K674 P678 H679 R709 I710 G711 N735
Binding residue
(residue number reindexed from 1)		Y7 P36 Y37 P90 V93 R97 Y112 D113 I114 P115 F116 K118 N205 N208 F209 M239 D241 R242 Y256 R260 T267 Y268 L270 D338 S343 K366 Y483 R596 R597 D598 E648 Q649 T651 R652 Y657 K658 P662 H663 R693 I694 G695 N719
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2xhb, PDBe:2xhb, PDBj:2xhb
PDBsum2xhb
PubMed20527806
UniProtP56689|DPOL_THEGO DNA polymerase (Gene Name=pol)

[Back to BioLiP]