Structure of PDB 2xbm Chain A Binding Site BS01

Receptor Information
>2xbm Chain A (length=261) Species: 12637 (Dengue virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTH
HAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRG
YTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSP
SPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGG
MLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIE
KDVDLGAGTRH
Ligand information
Receptor-Ligand Complex Structure
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PDB2xbm Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5'-Capped Octameric RNA
Resolution2.9 Å
Binding residue
(original residue number in PDB)		L17 N18 L20 S21 F25 S151 P152
Binding residue
(residue number reindexed from 1)		L15 N16 L18 S19 F23 S149 P150
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xbm, PDBe:2xbm, PDBj:2xbm
PDBsum2xbm
PubMed20862256
UniProtC0LMU5

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