Structure of PDB 2xax Chain A Binding Site BS01

Receptor Information
>2xax Chain A (length=728) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGI
KTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALY
DHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEG
KYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTF
KISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAG
IGINAGRIRALGSPFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMW
HLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPS
DVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERAST
GRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEI
ALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMG
RRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELA
KEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTH
GLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDY
EHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKV
PMQQLLKDLLTAYKFGVKTLYAQNTRDG
Ligand information
>2xax Chain D (length=16) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QIDSEVDTDDLSNFQL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2xax Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		L348 K584 K708 V709 M711 Q712 L719 K723
Binding residue
(residue number reindexed from 1)		L339 K575 K699 V700 M702 Q703 L710 K714
Enzymatic activity
Catalytic site (original residue number in PDB) C225 N437 C439 E441 C462 Y730 A731
Catalytic site (residue number reindexed from 1) C222 N428 C430 E432 C453 Y721 A722
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0044183 protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0009265 2'-deoxyribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
Cellular Component
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2xax, PDBe:2xax, PDBj:2xax
PDBsum2xax
PubMed20518462
UniProtP00452|RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha (Gene Name=nrdA)

[Back to BioLiP]