Structure of PDB 2xaw Chain A Binding Site BS01

Receptor Information
>2xaw Chain A (length=727) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGI
KTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALY
DHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEG
KYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTF
KISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAG
IGINAGRIRALGSPHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWH
LEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD
VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTG
RIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIA
LCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGR
RTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAK
EQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHG
LRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE
HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVP
MQQLLKDLLTAYKFGVKTLYFQNTRDG
Ligand information
Receptor-Ligand Complex Structure
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PDB2xaw Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		L347 L348 V396 K584 Q712 L719 Y722 K723
Binding residue
(residue number reindexed from 1)		L337 L338 V386 K574 Q702 L709 Y712 K713
Enzymatic activity
Catalytic site (original residue number in PDB) C225 N437 C439 E441 C462 Y730 F731
Catalytic site (residue number reindexed from 1) C222 N427 C429 E431 C452 Y720 F721
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0044183 protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0009265 2'-deoxyribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
Cellular Component
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xaw, PDBe:2xaw, PDBj:2xaw
PDBsum2xaw
PubMed20518462
UniProtP00452|RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha (Gene Name=nrdA)

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