Structure of PDB 2x6a Chain A Binding Site BS01

Receptor Information
>2x6a Chain A (length=274) Species: 188 (Paramagnetospirillum magnetotacticum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRILNSDGSSNITRLGLDDHYHDLLTVSWPVFITLITGLYLVTNALFALA
YLACGDVIENARPGSFTDAFFFSVQTMATIGYGKLIPIGPLANTLVTLEA
LCGMLGLAVAASLIYARFTRPTAGVLFSSRMVISDFEGKPTLMMRLANLR
IEAIIEADVHLVLVRSEVFRRFHDLTLTRSRSPIFSLSWTVMHPIDHHSP
IYGETDETLRNSHSEFLVLFTGHHEAFAQNVHARHAYSCDEIIWGGHFVD
VFTTLPDGRRALDLGKFHEIAQHH
Ligand information
Ligand IDPC
InChIInChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1
InChIKeyYHHSONZFOIEMCP-UHFFFAOYSA-O
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC[N+](C)(C)C
CACTVS 3.341C[N+](C)(C)CCO[P](O)(O)=O
OpenEye OEToolkits 1.5.0C[N+](C)(C)CCOP(=O)(O)O
FormulaC5 H15 N O4 P
NamePHOSPHOCHOLINE
ChEMBLCHEMBL1235161
DrugBankDB03945
ZINCZINC000001532692
PDB chain2x6a Chain A Residue 1298 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2x6a Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S205 S209 L210 W212
Binding residue
(residue number reindexed from 1)		S182 S186 L187 W189
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005242 inward rectifier potassium channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006813 potassium ion transport
GO:0034220 monoatomic ion transmembrane transport
GO:0034765 regulation of monoatomic ion transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2x6a, PDBe:2x6a, PDBj:2x6a
PDBsum2x6a
PubMed20564790
UniProtD9N164|IRK10_PARME Inward rectifier potassium channel Kirbac3.1

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