Structure of PDB 2wyi Chain A Binding Site BS01

Receptor Information
>2wyi Chain A (length=896) Species: 160490 (Streptococcus pyogenes M1 GAS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATKKVHIISHSHWDREWYMAYEQHHMRLINLIDDLLEVFQTDPDFHSFH
LDGQTIILDDYLKVRPEREPEIRQAIASGKLRIGPFYILQDDFLTSSESN
VRNMLIGKEDCDRWGASVPLGYFPDTFGNMGQTPQLMLKAGLQAAAFGRG
IRPTGFNNQVDTSEKYSSQFSEISWQGPDNSRILGLLFANWYSNGNEIPT
TEAEARLFWDKKLADAERFASTKHLLMMNGCDHQPVQLDVTKAIALANQL
YPDYEFVHSCFEDYLADLADDLPENLSTVQGEITSQETDGWYTLANTASA
RIYLKQANTRVSRQLENITEPLAAMAYEVTSTYPHDQLRYAWKTLMQNHP
HDSICGCSVDSVHREMMTRFEKAYEVGHYLAKEAAKQIADAIDTRDFPMD
SQPFVLFNTSGHSKTSVAELSLTWKKYHFGQRFPKEVYQEAQEYLARLSQ
SFQIIDTSGQVRPEAEILGTSIAFDYDLPKRSFREPYFAIKVRLRLPITL
PAMSWKTLALKLGNETVSLYDDSNQCLENGFLKVMIQTDGRLTITDKQSG
LIYQDLLRFEDCGDIGNEYISRQPNHDQPFYADQGTIKLNIISNTAQVAE
LEIQQTFAIPISADKLLQAEMEAVIDITERQARRSQEKAELTLTTLIRME
KNNPRLQFTTRFDNQMTNHRLRVLFPTHLKTDHHLADSIFETVKRPNHPD
ATFWKNPSNPQHQECFVSLFDGENGVTIGNYGLNEYEILPDTNTIAITLL
RSVGEMGDWGYFPTPEAQCLGKHSLSYSFESITKQTQFASYWRAQEGQVP
VITTQTNQHEGTLAAEYSYLTGTNDQVALTAFKRRLADNALITRSYNLSN
DKTCDFSLSLPNYNAKVTNLLEKDSKQSTPSQLGKAEILTLAWKKQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2wyi Chain A Residue 1906 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2wyi Structure and Kinetic Investigation of Streptococcus Pyogenes Family Gh38 Alpha-Mannosidase
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H13 D15 D125 H351
Binding residue
(residue number reindexed from 1)		H13 D15 D125 H351
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0009313 oligosaccharide catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wyi, PDBe:2wyi, PDBj:2wyi
PDBsum2wyi
PubMed20140249
UniProtQ99YP5

[Back to BioLiP]