Structure of PDB 2wq7 Chain A Binding Site BS01

Receptor Information

>2wq7 Chain A (length=508) Species: 7227 (Drosophila melanogaster)

DSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGRYFVRPIFILDPGIL
DWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWR
VEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCSHTIYNPELVIAKN
LGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYD
CPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAP
NSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLM
WREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFID
AIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWA
LNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPA
GCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVN
REVRTGKE

Ligand information

>2wq7 Chain C (length=15)

acagcggtcgcaggt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wq7 DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization Into (6-4) Lesions.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): K246 P247 P293 Q299 W302 H365 L366 H369 W409 Q418 R421 V422 Y423 S424 F428 K431
• Binding residue (residue number reindexed from 1): K245 P246 P292 Q298 W301 H364 L365 H368 W408 Q417 R420 V421 Y422 S423 F427 K430

Enzymatic activity

• Catalytic site (original residue number in PDB): Q299 W302 W330 H365 W384 W407
• Catalytic site (residue number reindexed from 1): Q298 W301 W329 H364 W383 W406
• Enzyme Commision number: 4.1.99.3: deoxyribodipyrimidine photo-lyase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003677 DNA binding
• GO:0003904 deoxyribodipyrimidine photo-lyase activity
• GO:0071949 FAD binding

Biological Process

• GO:0032922 circadian regulation of gene expression
• GO:0043153 entrainment of circadian clock by photoperiod

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:2wq7, PDBe:2wq7, PDBj:2wq7
• PDBsum: 2wq7
• PubMed: 20166732
• UniProt: Q8SXK5