Structure of PDB 2wok Chain A Binding Site BS01

Receptor Information

>2wok Chain A (length=553) Species: 1901 (Streptomyces clavuligerus)

PAPTTAGAGWDAGVGALVNPSRRRGGTLRLVSSADVDSLDPARTYYVWVW
LLQRLLNRTLMAYPTDPGPAGLVPAPDLAEGPGEVSDGGRTWTYRLRRGL
RYDDGTPITSDDVRHAVQRVFAQDVLPGGPTYLIPLLDDPERPYPGPYRT
DEPLRSVLTPDEHTIVFRLTRPFSDFDHLMAQPCAAPVPRRSDTGADYGR
DPRSSGPYRVARHEPDTLLHLERNPHWDRATDPIRPALPDRVELTIGLDV
DVLDARLIAGEFDINLEGRGLQHAAQRRATADEVLRSHTDNPRTSFLHFV
AMQPHIPPFDNVHVRRAVQYAADKILLQDARGGPVNGGDLTTALFPPTLP
AHQDLDLYPTGPDLRGDLDAARAELAAAGLPDGFRAVIGTQRGKFRLVAD
AVVESLARVGIELTVKELDVATYFSLGAGHPETVREHGLGLLVTDWGADF
PTEYGFLAPLVDGRQIKRNGGNWNLPELDDPEVNALIDETLHTTDPAARA
ELWRAVERRVMEHAVLLPLVHDKTLHFRNPWVTNVYVHPAFGLYDIQAMG
LAE

Ligand information

>2wok Chain B (length=6) Species: 9606 (Homo sapiens)

RPPGFR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wok Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): Y52 V54 W57 F303 F402 F431 D452 W453 G454 D456 W480
• Binding residue (residue number reindexed from 1): Y45 V47 W50 F296 F395 F424 D445 W446 G447 D449 W473

Gene Ontology

Molecular Function

• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0033050 clavulanic acid biosynthetic process
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:2wok, PDBe:2wok, PDBj:2wok
• PDBsum: 2wok
• PubMed: 19941870
• UniProt: Q8KRB4