Structure of PDB 2wjz Chain A Binding Site BS01

Receptor Information
>2wjz Chain A (length=251) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFL
DITASVEKRKTMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKV
SINTAAVENPSLITQIAQTFGSQAVVVAIDAKRVDGEFMVFTYSGKKNTG
ILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIA
SGGAGKMEHFLEAFLAGADAALAASVFHFREIDVRELKEYLKKHGVNVRL
E
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain2wjz Chain A Residue 1252 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2wjz Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		G82 N103 T104
Binding residue
(residue number reindexed from 1)		G82 N103 T104
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D11 D130
Catalytic site (residue number reindexed from 1) D11 D130
Enzyme Commision number 4.3.2.10: imidazole glycerol-phosphate synthase.
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wjz, PDBe:2wjz, PDBj:2wjz
PDBsum2wjz
PubMed23261602
UniProtQ9X0C6|HIS6_THEMA Imidazole glycerol phosphate synthase subunit HisF (Gene Name=hisF)

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