Structure of PDB 2whx Chain A Binding Site BS01

Receptor Information
>2whx Chain A (length=582) Species: 11070 (dengue virus type 4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVYRIMQRGLFGKTQVGVGIHMEGVFHTMWHVTRGSVICHERLEPSWADV
RNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLFEIGAVT
LDFKPGTSGSPIINKKGKVIGLYGNVSAITQAERIGEPDYEVDEDIFRKK
RLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALR
GLPIRYQTPAVKSDHTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEA
HFTDPCSVAARGYISTRVEMGEAAAIFMTATPPGSTDPFPQSNSPIEDIE
REIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSGKRVIQLS
RKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTD
GPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHA
HWTEAKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQRKTFVEL
MRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEVEIWTREG
EKKKLRPKWLDARVYADPMALKDFKEFASGRK
Ligand information
>2whx Chain C (length=14) Species: 11070 (dengue virus type 4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADLSLEKAANVQWD
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2whx Flexibility between the Protease and Helicase Domains of the Dengue Virus Ns3 Protein Conferred by the Linker Region and its Functional Implications.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		V22 Y23 R24 I25 M26 Q27 R28 F46 I58 C59 V95 Q96 I100 H108 Q110 I140 N141
Binding residue
(residue number reindexed from 1)		V2 Y3 R4 I5 M6 Q7 R8 F26 I38 C39 V73 Q74 I78 H86 Q88 I113 N114
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2whx, PDBe:2whx, PDBj:2whx
PDBsum2whx
PubMed20375022
UniProtQ2YHF0|POLG_DEN4T Genome polyprotein

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