Structure of PDB 2wfr Chain A Binding Site BS01

Receptor Information
>2wfr Chain A (length=165) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFK
DEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQD
SLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKA
DNSLAVKLEHHHHHH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2wfr Chain A Residue 1204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2wfr Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Resolution1.95 Å
Binding residue
(original residue number in PDB)		H141 D148 H183
Binding residue
(residue number reindexed from 1)		H103 D110 H145
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:2wfr, PDBe:2wfr, PDBj:2wfr
PDBsum2wfr
PubMed19561611
UniProtO43323|DHH_HUMAN Desert hedgehog protein (Gene Name=DHH)

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