Structure of PDB 2wa7 Chain A Binding Site BS01

Receptor Information
>2wa7 Chain A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKR
MYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLIL
GLVWTLILHYSISMPVWEDEGKKQTPKQRLLGWIQNKIPYLPITNFNQNW
QDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAVQQADDWLGVPQVI
TPEEIIHPDVDEHSVMTYLSQFPKA
Ligand information
Ligand IDCO3
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)([O-])[O-]
ACDLabs 10.04
CACTVS 3.341		[O-]C([O-])=O
FormulaC O3
NameCARBONATE ION
ChEMBL
DrugBankDB14531
ZINC
PDB chain2wa7 Chain A Residue 1243 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2wa7 Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		W189 E200
Binding residue
(residue number reindexed from 1)		W174 E185
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding
Biological Process
GO:0030036 actin cytoskeleton organization

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wa7, PDBe:2wa7, PDBj:2wa7
PDBsum2wa7
PubMed19505475
UniProtO75369|FLNB_HUMAN Filamin-B (Gene Name=FLNB)

[Back to BioLiP]