Structure of PDB 2wa5 Chain A Binding Site BS01

Receptor Information
>2wa5 Chain A (length=237) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLR
LIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDS
KAIVDGNLKLILGLVWTLILHYSISMPVWEDEKQTPKQRLLGWIQNKIPY
LPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQA
DDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKL
Ligand information
Ligand IDCO3
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)([O-])[O-]
ACDLabs 10.04
CACTVS 3.341		[O-]C([O-])=O
FormulaC O3
NameCARBONATE ION
ChEMBL
DrugBankDB14531
ZINC
PDB chain2wa5 Chain A Residue 1244 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2wa5 Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		E218 I221 H222
Binding residue
(residue number reindexed from 1)		E213 I216 H217
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding
Biological Process
GO:0030036 actin cytoskeleton organization

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Molecular Function
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Biological Process
External links
PDB RCSB:2wa5, PDBe:2wa5, PDBj:2wa5
PDBsum2wa5
PubMed19505475
UniProtO75369|FLNB_HUMAN Filamin-B (Gene Name=FLNB)

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