Structure of PDB 2w5z Chain A Binding Site BS01
Receptor Information
>2w5z Chain A (length=180) Species:
9606
(Homo sapiens) [
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EYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIH
GRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDD
SEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEE
LTYDYKFPIEDASNKLPCNCGAKKCRKFLN
Ligand information
>2w5z Chain C (length=8) Species:
9606
(Homo sapiens) [
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RTKQTARY
Receptor-Ligand Complex Structure
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PDB
2w5z
Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
M3884 F3885 R3886 I3887 D3888 R3903 I3905 S3915 V3917 I3926 Y3942 D3943 Y3944 K3945 F3946
Binding residue
(residue number reindexed from 1)
M95 F96 R97 I98 D99 R114 I116 S126 V128 I137 Y153 D154 Y155 K156 F157
Enzymatic activity
Catalytic site (original residue number in PDB)
Y3858 Y3944
Catalytic site (residue number reindexed from 1)
Y69 Y155
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:2w5z
,
PDBe:2w5z
,
PDBj:2w5z
PDBsum
2w5z
PubMed
19187761
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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