Structure of PDB 2w42 Chain A Binding Site BS01

Receptor Information
>2w42 Chain A (length=395) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTYRIGNGASVPISNTGELIKGLRNYGPYEVPSLKYNQIALIHNNQFSSL
INQLKSQISSKIDEVWHIHNINISEFIYDSPHFDSIKSQVDNAIDTGVDG
IMLVLPEYNTPLYYKLKSYLINSIPSQFMRYDILSNRNLTFYVDNLLVQF
VSKLGGKPWILNVDPEKGSDIIIGTGATRIDNVNLFCFAMVFKKDGTMLW
NEISPIVTSSEYLTYLKSTIKKVVYGFKKSNPDWDVEKLTLHVSGKRPKM
KDGETKILKETVEELKKQEMVSRDVKYAILHLNETHPFWVMGYEGTKVKL
SSKRYLLTLLQMVTPIKPLSVEIVSDNWTSEEYYHNVHEILDEIYYLSKM
NWRGFRSRNLPVTVNYPKLVAGIIANVNRYGGYPIRSLQTNPWFL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2w42 Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y118 Y123 Y124 K127 Q137 F138 M139 R140 I143 Y152 N155 L156 Q159 K163 N378 R380 R385 L427
Binding residue
(residue number reindexed from 1)		Y108 Y113 Y114 K117 Q127 F128 M129 R130 I133 Y142 N145 L146 Q149 K153 N351 R353 R358 L395
Binding affinityPDBbind-CN: Kd=29.2nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2w42, PDBe:2w42, PDBj:2w42
PDBsum2w42
PubMed19187762
UniProtO28951|PIWI_ARCFU Piwi protein (Gene Name=AF_1318)

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