Structure of PDB 2vux Chain A Binding Site BS01

Receptor Information
>2vux Chain A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEEPLLRKVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKAD
EKYFISHILAFFAASNLVERFSQEVQVPEARCFYGFQILIENVHSEMYSL
LIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAF
AAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVA
DRLLVELGFSKVFQAENPFDFM
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain2vux Chain A Residue 1313 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2vux Human Ribonucleotide Reductase, Subunit M2 B
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E131 E194 E228 H231
Binding residue
(residue number reindexed from 1)		E91 E154 E188 H191
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y138 D227
Catalytic site (residue number reindexed from 1) Y98 D187
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2vux, PDBe:2vux, PDBj:2vux
PDBsum2vux
PubMed
UniProtQ7LG56|RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B (Gene Name=RRM2B)

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