Structure of PDB 2vqx Chain A Binding Site BS01

Receptor Information

>2vqx Chain A (length=322) Species: 28151 (Serratia proteamaculans)

ARSVIPPYMLRRIIEHGSLPQRDCALHTLNHVKTSTGGEVIRDIYDAENS
TQLPGKQVRNEGQASNHDVAVDEAYDYLGVTYDFFWQAFKRNSLDNQGLP
LTGSVHYGKEYQNAFWNGQQMVFGDGDGEIFNRFTIAIDVVGHALAHGVT
ESEAGLIYFQQAGALNESLSDVFGSLVKQFHLKQTADKADWLIGEGLLAK
GINGKGLRSMSAPGTAYDDPLLGKDPQPASMKDYIQTKEDNGGVHLNSGI
PNRAFYLAATALGGYAWEKAGYIWYDTLCDKALPQDADFATFARTTVKHA
EQRFDSKVAQKVQQAWHQVGVA

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2vqx Chain A Residue 1342

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2vqx Crystal Structure of the Protealysin Precursor: Insights Into Propeptide Function.
• Resolution: 1.821 Å
• Binding residue (original residue number in PDB): H162 H166 E186
• Binding residue (residue number reindexed from 1): H143 H147 E167
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H162 A163 H166 Y177 E186 D259 H264
• Catalytic site (residue number reindexed from 1): H143 A144 H147 Y158 E167 D240 H245
• Enzyme Commision number: 3.4.24.-

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2vqx, PDBe:2vqx, PDBj:2vqx
• PDBsum: 2vqx
• PubMed: 19915005
• UniProt: Q5MJ80