Structure of PDB 2vmk Chain A Binding Site BS01

Receptor Information
>2vmk Chain A (length=489) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRMLINATQQEELRVALVDGQRLYDLDIESEQKKANIYKGKITRIEPSL
EAAFVDYGAERHGFLPLKEIAREYFPRPNIKDVLREGQEVIVQIDKEERG
NKGAALTTFISLAGSYLVLMPNNPRAGGISRRIRTELKEALASLELPEGM
GLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQESNVI
VRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKLYTGEIP
LFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSARDIEETA
FNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENRLREAVRQ
DRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDNESL
SLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQDGV
RCVIVPNDQMETPHYHVLRVRKGEETPTLSYMLPKLHEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2vmk Chain B Residue 1514 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2vmk The Crystal Structure of the Escherichia Coli Rnase E Apoprotein and a Mechanism for RNA Degradation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C404 C407
Binding residue
(residue number reindexed from 1)		C385 C388
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2vmk, PDBe:2vmk, PDBj:2vmk
PDBsum2vmk
PubMed18682225
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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