Structure of PDB 2v64 Chain A Binding Site BS01

Receptor Information
>2v64 Chain A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHHGSALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFT
RVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESG
EVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPL
LEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVN
SMVAYKIPVN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2v64 The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
Resolution2.9 Å
Binding residue
(original residue number in PDB)		I37 Y38 Y64 F151 D152 L153 L154 I155 Y156 T157 K159 V163 W167 E168 S170 P172 V203 N204
Binding residue
(residue number reindexed from 1)		I43 Y44 Y70 F157 D158 L159 L160 I161 Y162 T163 K165 V169 W173 E174 S176 P178 V209 N210
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000132 establishment of mitotic spindle orientation
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0042177 negative regulation of protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045930 negative regulation of mitotic cell cycle
GO:0051301 cell division
GO:0051660 establishment of centrosome localization
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:1904667 negative regulation of ubiquitin protein ligase activity
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0033597 mitotic checkpoint complex
GO:0044615 nuclear pore nuclear basket
GO:0048471 perinuclear region of cytoplasm
GO:0072686 mitotic spindle
GO:1990728 mitotic spindle assembly checkpoint MAD1-MAD2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2v64, PDBe:2v64, PDBj:2v64
PDBsum2v64
PubMed18022367
UniProtQ13257|MD2L1_HUMAN Mitotic spindle assembly checkpoint protein MAD2A (Gene Name=MAD2L1)

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