Structure of PDB 2v3u Chain A Binding Site BS01

Receptor Information
>2v3u Chain A (length=253) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEI
YVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTT
RYMDYSVGVLLRRGTSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNP
FERDSMYSQMWRMINRNNVLESQAGIQKVKYGNYAFVWDAAVLEYVAIND
PDCSFYTVGADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWP
KNG
Ligand information
Ligand IDDSN
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKeyMTCFGRXMJLQNBG-UWTATZPHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C([C@H](C(=O)O)N)O
CACTVS 3.341N[C@H](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
ACDLabs 10.04O=C(O)C(N)CO
FormulaC3 H7 N O3
NameD-SERINE
ChEMBLCHEMBL285123
DrugBankDB03929
ZINCZINC000000895342
PDB chain2v3u Chain A Residue 1262 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2v3u Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine.
Resolution1.74 Å
Binding residue
(original residue number in PDB)		Y58 A85 T87 R92 Y105 S137 A138 V139 W193 D194
Binding residue
(residue number reindexed from 1)		Y58 A85 T87 R92 Y105 S137 A138 V139 W188 D189
Annotation score4
Binding affinityMOAD: Kd=1mM
PDBbind-CN: -logKd/Ki=3.00,Kd=1mM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2v3u, PDBe:2v3u, PDBj:2v3u
PDBsum2v3u
PubMed17715062
UniProtQ63226|GRID2_RAT Glutamate receptor ionotropic, delta-2 (Gene Name=Grid2)

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