Structure of PDB 2v26 Chain A Binding Site BS01

Receptor Information
>2v26 Chain A (length=747) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPVWAPHPTDGFQVGNIVDIGPDSLTIEPGKTFLALINQVFPAEEDSKKD
VEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYS
SETIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKLSQSIIVSGESGAGKT
ENTKFVLRYLTESYGDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHF
NEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIRERLH
LSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSLKDPLLDDH
GDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNL
KNKSTQALEYCAELLGLDQDDLRVSLTTRVMIKVPLKVEQANNARDALAK
TVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINY
CNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEARLVGI
LDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIPRKSKLAIHRNIRDDE
GFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFLSFI
SVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQC
SGMVSVLDLMQGGFPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKA
LGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain2v26 Chain A Residue 1789 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2v26 The Structural Basis for the Large Powerstroke of Myosin Vi.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		N98 P99 F101 G154 G156 K157 T158 E159 F163 N200
Binding residue
(residue number reindexed from 1)		N90 P91 F93 G146 G148 K149 T150 E151 F155 N186
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S153 G154 T158 N200 S203 S204 G459 E461
Catalytic site (residue number reindexed from 1) S145 G146 T150 N186 S189 S190 G434 E436
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:2v26, PDBe:2v26, PDBj:2v26
PDBsum2v26
PubMed17956731
UniProtQ29122|MYO6_PIG Unconventional myosin-VI (Gene Name=MYO6)

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