Structure of PDB 2v1d Chain A Binding Site BS01

Receptor Information

>2v1d Chain A (length=666) Species: 9606 (Homo sapiens)

PSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQL
WLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRI
KPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATF
RKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAV
PKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKP
PRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVY
LSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNG
YSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDA
VLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVF
WDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSG
NDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLR
EAGRIADQFLGAMYTL

Ligand information

>2v1d Chain C (length=16) Species: 9606 (Homo sapiens)

ARTMQTARKSTGGKAP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2v1d Structural Basis of Lsd1-Corest Selectivity in Histone H3 Recognition.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): Q358 C360 D375 E379 N383 L386 E387 N535 A539 N540 W552 D553 D555 D556 H564 L677 A809
• Binding residue (residue number reindexed from 1): Q188 C190 D205 E209 N213 L216 E217 N365 A369 N370 W382 D383 D385 D386 H394 L507 A639

Enzymatic activity

• Catalytic site (original residue number in PDB): T335
• Catalytic site (residue number reindexed from 1): T165
• Enzyme Commision number: 1.14.99.66: [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:2v1d, PDBe:2v1d, PDBj:2v1d
• PDBsum: 2v1d
• PubMed: 17537733
• UniProt: O60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A (Gene Name=KDM1A)