Structure of PDB 2uy8 Chain A Binding Site BS01

Receptor Information

>2uy8 Chain A (length=377) Species: 1423 (Bacillus subtilis)

DIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGTVSNMKFSFSDT
HNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIAELHWHKEAEWAYM
IYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVF
DDGSFSENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQ
LPGSLKDDIVEGPNGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSK
TIASALVTVEPGAMRELHWHPNTHEWQYYISGKARMTVFASDGHARTFNY
QAGDVGYVPFAMGHYVENIGDEPLVFLEIFKDDHYADVSLNQWLAMLPET
FVQAHLDLGKDFTDVLSKEKHPVVKKK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2uy8 Chain A Residue 1383

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2uy8 The Identity of the Active Site of Oxalate Decarboxylase and the Importance of the Stability of Active-Site Lid Conformations.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): H95 H97 E101 H140
• Binding residue (residue number reindexed from 1): H90 H92 E96 H135
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): A92 H95 H97 E101 H140 E162
• Catalytic site (residue number reindexed from 1): A87 H90 H92 E96 H135 E157
• Enzyme Commision number: 4.1.1.2: oxalate decarboxylase.

Gene Ontology

Molecular Function

• GO:0016831 carboxy-lyase activity
• GO:0046564 oxalate decarboxylase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0033609 oxalate metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2uy8, PDBe:2uy8, PDBj:2uy8
• PDBsum: 2uy8
• PubMed: 17680775
• UniProt: O34714|OXDC_BACSU Oxalate decarboxylase OxdC (Gene Name=oxdC)