Structure of PDB 2uxn Chain A Binding Site BS01

Receptor Information

>2uxn Chain A (length=664) Species: 9606 (Homo sapiens)

GVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWL
DNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKP
LPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRK
GNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPK
EKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKH
VKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPR
DITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLS
SRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYS
CVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVL
CTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWD
PSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDV
IVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGND
YDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREA
GRIADQFLGAMYTL

Ligand information

>2uxn Chain E (length=7) Species: 9606 (Homo sapiens)

ARTKQTA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2uxn Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.
• Resolution: 2.72 Å
• Binding residue (original residue number in PDB): Q358 N535 A539 N540 W552 D556 H564 Y761
• Binding residue (residue number reindexed from 1): Q186 N363 A367 N368 W380 D384 H392 Y589

Enzymatic activity

• Catalytic site (original residue number in PDB): T335 D553 K661
• Catalytic site (residue number reindexed from 1): T163 D381 K489
• Enzyme Commision number: 1.14.99.66: [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:2uxn, PDBe:2uxn, PDBj:2uxn
• PDBsum: 2uxn
• PubMed: 17529991
• UniProt: O60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A (Gene Name=KDM1A)