Structure of PDB 2uw8 Chain A Binding Site BS01
Receptor Information
>2uw8 Chain A (length=337) Species:
9913
(Bos taurus) [
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SVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHM
ETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLTKLEFSFKDN
SNLYMVMEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLI
YRDLKPENLMIDQQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK
GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS
DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP
FIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Ligand information
>2uw8 Chain I (length=20) Species:
9606
(Homo sapiens) [
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TTYADFIASGRTGRRNAIHD
Receptor-Ligand Complex Structure
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PDB
2uw8
Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
E127 F129 R133 E170 F187 L198 G200 T201 P202 E203 E230 Y235 F239 D241 I246 D328 Y330
Binding residue
(residue number reindexed from 1)
E114 F116 R120 E157 F174 L185 G187 T188 P189 E190 E217 Y222 F226 D228 I233 D315 Y317
Enzymatic activity
Catalytic site (original residue number in PDB)
D166 K168 E170 N171 D184 T201
Catalytic site (residue number reindexed from 1)
D153 K155 E157 N158 D171 T188
Enzyme Commision number
2.7.11.11
: cAMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004679
AMP-activated protein kinase activity
GO:0004691
cAMP-dependent protein kinase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0019904
protein domain specific binding
GO:0034237
protein kinase A regulatory subunit binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0001707
mesoderm formation
GO:0006468
protein phosphorylation
GO:0010737
protein kinase A signaling
GO:0016310
phosphorylation
GO:0018105
peptidyl-serine phosphorylation
GO:0034605
cellular response to heat
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0001669
acrosomal vesicle
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0005952
cAMP-dependent protein kinase complex
GO:0031594
neuromuscular junction
GO:0036126
sperm flagellum
GO:0048471
perinuclear region of cytoplasm
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:2uw8
,
PDBe:2uw8
,
PDBj:2uw8
PDBsum
2uw8
PubMed
17451234
UniProt
P00517
|KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha (Gene Name=PRKACA)
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