Structure of PDB 2uw2 Chain A Binding Site BS01

Receptor Information
>2uw2 Chain A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVEDEPLLRENPIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESL
KPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAME
NIHSEMYSLLIDTYIKDPKEREFLMPCVKKKADWALRWIGDKEATYGERV
VAFAAVEGIFFSGSFASIFWLKKRGPMPGLTFSNELISRDEGLHCDFACL
MFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIE
FVADRLMLELGFSKVFRVENPFDFM
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain2uw2 Chain A Residue 1351 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2uw2 Crystal Structure of Human Ribonucleotide Reductase Subunit R2
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E169 E232 E266 H269
Binding residue
(residue number reindexed from 1)		E100 E157 E191 H194
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y176
Catalytic site (residue number reindexed from 1) Y107
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2uw2, PDBe:2uw2, PDBj:2uw2
PDBsum2uw2
PubMed
UniProtP31350|RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (Gene Name=RRM2)

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