Structure of PDB 2rdn Chain A Binding Site BS01

Receptor Information

>2rdn Chain A (length=275) Species: 33903 (Streptomyces avermitilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TNVTGDYTDCTPLLGDRAALDSFYEEHGYLFLRNVLDRDLVKTVAEQMRE
GLVALGAADPHATLEELTIDSFESVDEVAMHDYVKYDAFWNNPSTIKVFE
QVFGEPVFVFLSTTIRYYPSQAGSEEPSFHYLTPFHQDGFYIGPNQDFRT
FWIPLIRTTRESGGVALADGSHRRGKRDHVLNESFRRFGHPVRGIPPTEV
SEDEHLLHSPMEPGDILLFHAHMCHKSIPNLSKDPRLMRMSMDTRVQPAK
SHRGFNAMTPWTESAKDASKGIMAK

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

2rdn Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2rdn Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis.
Resolution	1.35 Å
Binding residue (original residue number in PDB)	H137 D139 H226
Binding residue (residue number reindexed from 1)	H136 D138 H225
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.35: 1-deoxypentalenic acid 11beta-hydroxylase.

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0016706	2-oxoglutarate-dependent dioxygenase activity
GO:0031418	L-ascorbic acid binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

	Biological Process
GO:0017000	antibiotic biosynthetic process
GO:1901336	lactone biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:2rdn, PDBe:2rdn, PDBj:2rdn
PDBsum	2rdn
PubMed	17942405
UniProt	Q82IZ1\|PTLH_STRAW 1-deoxypentalenic acid 11-beta-hydroxylase (Gene Name=ptlH)

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