Structure of PDB 2rca Chain A Binding Site BS01

Receptor Information
>2rca Chain A (length=282) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAAL
VNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRW
TGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRGTE
LSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTP
HGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIG
LPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain2rca Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2rca Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Resolution1.58 Å
Binding residue
(original residue number in PDB)		Y95 S123 R128 S177 S178 D222
Binding residue
(residue number reindexed from 1)		Y92 S120 R125 S174 S175 D219
Annotation score4
Binding affinityMOAD: Kd=16.4nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2rca, PDBe:2rca, PDBj:2rca
PDBsum2rca
PubMed18636091
UniProtQ8VHN2|NMD3B_RAT Glutamate receptor ionotropic, NMDA 3B (Gene Name=Grin3b)

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