Structure of PDB 2rc9 Chain A Binding Site BS01

Receptor Information
>2rc9 Chain A (length=287) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSL
HSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNG
HWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRG
TELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPA
TPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYG
IGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVV
Ligand information
Ligand ID1AC
InChIInChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
InChIKeyPAJPWUMXBYXFCZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1(CC1)C(O)=O
OpenEye OEToolkits 1.5.0C1CC1(C(=O)O)N
ACDLabs 10.04O=C(O)C1(N)CC1
FormulaC4 H7 N O2
Name1-AMINOCYCLOPROPANECARBOXYLIC ACID
ChEMBLCHEMBL265325
DrugBankDB02085
ZINCZINC000000895536
PDB chain2rc9 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2rc9 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		Y97 S123 F124 S125 R130 S179 S180 M223 D224
Binding residue
(residue number reindexed from 1)		Y94 S120 F121 S122 R127 S176 S177 M220 D221
Annotation score1
Binding affinityPDBbind-CN: -logKd/Ki=7.40,IC50=0.04uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:2rc9, PDBe:2rc9, PDBj:2rc9
PDBsum2rc9
PubMed18636091
UniProtQ9R1M7|NMD3A_RAT Glutamate receptor ionotropic, NMDA 3A (Gene Name=Grin3a)

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