Structure of PDB 2rap Chain A Binding Site BS01

Receptor Information
>2rap Chain A (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSP
SVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQI
IRVKRYEKVPVILVGNKVDLESEREVSSSEGRALAEEWGCPFMETSAKSK
TMVDELFAEIVRQMNYA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2rap Chain A Residue 181 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2rap Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		S17 T35
Binding residue
(residue number reindexed from 1)		S17 T35
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0030033 microvillus assembly
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032486 Rap protein signal transduction
GO:0045184 establishment of protein localization
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0046328 regulation of JNK cascade
GO:0048814 regulation of dendrite morphogenesis
GO:0051963 regulation of synapse assembly
GO:0071466 cellular response to xenobiotic stimulus
GO:0072659 protein localization to plasma membrane
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Cellular Component
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030496 midbody
GO:0030659 cytoplasmic vesicle membrane
GO:0045202 synapse
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0097060 synaptic membrane
GO:0098588 bounding membrane of organelle
GO:0098685 Schaffer collateral - CA1 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2rap, PDBe:2rap, PDBj:2rap
PDBsum2rap
PubMed9312017
UniProtP10114|RAP2A_HUMAN Ras-related protein Rap-2a (Gene Name=RAP2A)

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