Structure of PDB 2r7w Chain A Binding Site BS01

Receptor Information
>2r7w Chain A (length=1073) Species: 10922 (Simian rotavirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKYNLILSEYLSFIYNSVQIPIYYSSNSELENRCIEFHSKCLENSKNGLS
LRKLFVEYNDVIENATLLSILSYSYDKYNAVERKLVKYAKGKPLEADLTV
NELDYENNKMTSELFPTAEEYTDSLMDPAILTSLSSNLNAVMFWLEKHEN
DVAEKLKVYKRRLDLFTIVASTINKYGVPRHNAKYRYEYDVMKDKPYYLV
TWANSSIEMLMSVFSHDDYLIAKELIVLSYSNRSTLAKLVSSPMSILVAL
VDINGTFITNEELELEFSNKYVRAIVPDQTFDELNQMLDNMRKAGLVDIP
KMIQDWLVDRSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQEMYREYTM
LIRDEVVKMLEEPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTI
FSTKKNMHVMDDMANERYTPGIIPPVNVDKPIPLGRRDVPGRRTRIIFIL
PYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNTM
VLYTDVSQWDSSQHNTQPFRKGIIMGLDILANMTNDAKVLQTLNLYKQTQ
INLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRI
SNKHSFATKIIRVDGDDNYAVLQFNTEVTKQMIQDVSNDVRETYARMNAK
VKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYS
NYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNSTFKV
FDSEDFIIEYGTTVDEVYIQRAFMSLSSQKSGIADEIAASSTFKNYVTRL
SEQLLFSKNNIVSRGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPV
TFKSSKITINDILRDIKPFFTVSDAHLPIQYQKFMPTLPDNVQYIIQCIG
SRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLYLISL
GIPKIDADTYVGSKIYSRDKYRILESYVYNLLSINYGCYQLFDFNSPDLE
KLIRIPFKGKIPAVTFILHLYAKLEVINYAIKNGSWISLFCNYPKSEMIK
LWKKMWNITSLRSPYTNANFFQE
Ligand information
Receptor-Ligand Complex Structure
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PDB2r7w Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K188 R190 S398 A400 S401 I415 F416 T418 K420 I462 G592 K594 R701 G702 Y842 P844
Binding residue
(residue number reindexed from 1)		K184 R186 S383 A385 S386 I400 F401 T403 K405 I447 G577 K579 R686 G687 Y827 P829
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2r7w, PDBe:2r7w, PDBj:2r7w
PDBsum2r7w
PubMed19000820
UniProtO37061|RDRP_ROTSP RNA-directed RNA polymerase

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