Structure of PDB 2r6m Chain A Binding Site BS01

Receptor Information
>2r6m Chain A (length=176) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDL
EQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCEN
QPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHM
LFMVHPEYRPKRPANQFVPRLYGFKI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2r6m Chain A Residue 216 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2r6m Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C109 C114 C137 C140
Binding residue
(residue number reindexed from 1)		C93 C98 C121 C124
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0004674 protein serine/threonine kinase activity
GO:0005102 signaling receptor binding
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0033211 adiponectin-activated signaling pathway
GO:0033574 response to testosterone
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0061154 endothelial tube morphogenesis
GO:0075342 symbiont-mediated disruption of host cell PML body
GO:0097421 liver regeneration
GO:1903901 negative regulation of viral life cycle
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005956 protein kinase CK2 complex
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0031519 PcG protein complex
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2r6m, PDBe:2r6m, PDBj:2r6m
PDBsum2r6m
PubMed
UniProtP67874|CSK2B_RAT Casein kinase II subunit beta (Gene Name=Csnk2b)

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